League leaders Leicester City travel to the Etihad where City also boast a 100% record, admittedly after just one game of the season.
Meanwhile, Bramall Lane is the setting for a Yorkshire derby as Sheffield United and Leeds meet in the top-flight for the first time in 26 years.
Newcastle will be looking to repeat their shock win at Spurs when they head to the Tottenham Hotspur Stadium to face the potent forward line of Harry Kane and Son Heung-Min.
All this as David Moyes prepares for his side’s game with Wolves vis Zoom having contacted Coronavirus last week.
Sheffield United v Leeds, 12:30
With Sheff Utd somewhat bereft of the confidence after three winless games, Leeds have a real chance for a morale-boosting derby win in Sunday’s lunctime opener.
Marcelo Bielsa’s side find themselves above their Yorkshire rivals courtesy of their 4-3 win over Fulham, with Sheffield Utd having neither claimed a point nor scored a goal in their two Premier League fixtures.
The last time these two were both in the Championship each side claimed a 1-0 victory, though the Blades did have the last laugh, emerging from the Championship as league winners, with Leeds missing out in the play-offs.
Sheffield United win: 2.70
Leeds win: 2.65
Tottenham v Newcastle, 14:00
Harry Kane and Son Heung-Min’s devastating afternoon at St. Mary’s during which the former assisted the latter for four goals resulted in a much-needed win for Spurs who’d been dreadful on opening day against Everton.
After an encouraging 2-0 win at West Ham on the opening day, Newcastle failed to register a shot on target in their home fixture with Brighton and will be missing Allan Saint-Maximin for this one through injury.
However, the Magpies will be looking at the corresponding fixture last season when they came away from North London with all three points after a 1-0 victory.
Spurs win: 1.46
Newcastle win: 7.00
Manchester City v Leicester, 16:30
Leicester sit top of the table after comfortable wins over West Brom and Burnley but the Foxes have never won their first three matches of a top-flight campaign as they prepare for a trip to the Etihad.
The Foxes are also winless in their last four trips to the Etihad since their 3-1 win in the 2015/16 title-winning campaign, though Jamie Vardy, the only player ever to score a top-flight hat-trick against a Pep Guardiola side, has five goals and an assist in his last eight appearances against City.
Sergio Aguero will miss-out once more, but Gabriel Jesus, who scored against Wolves last week, has proved to be more than an able deputy with City winning 34 of the 35 Premier League games in which he has found the net.
Man City win: 1.29
Leicester win: 9.50
West Ham v Wolves, 19:00
The figures make pretty bleak reading for West Ham ahead of this one as Wolves have beaten the Irons four times in a row without conceding a goal while Raul Jimenez has netted in each of his last three appearances against them.
The Hammers defensive woes have seen them fail to keep a clean sheet in all 10 home games since Moyes’ first game back but it’s not so bad going forward with only Liverpool (52) and Everton (44) have had more shots than the Hammers this season (40).
It’s been a tough week on and off the field for the Hammers with players and staff, including Moyes, being struck down with coronavirus and they will be hoping their luck will finally change on Sunday night against a side who were beaten by Manchester City last time out.
West Ham win: 3.80
Wolves win: 2.05
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